Study on the Effect of Exercise and Tea Extracts on Skin Wound Repair

Abstract

So far, a lot of research has been done on the effect of drugs and surgical procedures on the treatment of various types of ulcers, especially diabetic wounds. In his study, the effects of green tea extract (Camellia Sinesis L.) that has been widely used in different countries have been investigated and several pharmacological effects have been reported. Fifty male mice each weighing approximately 30-35 grams evaluated as adult and Healthy were divided into five groups: Healthy and Sedentary; diabetic and Sedentary; diabetic and sport; diabetic and green tea; and diabetic, sport with green tea extract. In all groups, a square shaped cut was made behind the neck of mice equal to the size of the wound cut by a surgical blade. To analyze the key roles of exercise and green tea extract in wound healing in diabetic mice, on days 14-21-14, mice were killed and after a macroscopic examination and observation of wounds, they were given a lam and a review. Microscopy has also been done. The results analyzed by ANOVA test showed that the comparison of the mean area of the control group with the training groups with treadmill exercises and the groups of enameled tea extract and showed a significant difference (P = 0.4773) and (P = 0.555), and the density of blood vessels. The epidermis was more common in these groups than in the control group and in the diabetic and dietetic group, and the combination of two factors of exercise and the use of green tea extract on the wound showed that the repair was done on day 14 and the wound healing rate 2 times faster. One of the most important factors in the healing process of wound healing is the use of medicinal herbs such as green tea extract. These medicinal herbs and also because of the presence of antioxidants, which are 100 times more effective than vitamin C and 25 times more effective than vitamin E. The chemical structure of these molecules is green tea polyphenols, which initiates the antioxidant hypothesis. EGCG (Epigaloccatin Galate) is the main component of polyphenolic green tea that contains antioxidant, anti-tumor and anti-mutagenic. EGCG is proved to be inhibitor of chymotrypsin, a factor in tumor necrosis alpha, glucose 6- Liver phosphatase, non-acceptance of transplantation in humans and lipid peroxidase. Research shows that green tea can reduce blood sugar, blood lipids, blood pressure, reduce cardiovascular disease, heart rate, and also vasodilatation. This affects the practical capacity of fibroblasts, increases the Synthesis of collagen fibers, and enhances the resistance of the wound due to increased collagen content, and since fibroblasts are responsible for creating collagen fibers. Exercise also boosts vascularity and enhances oxygenation. Therefore, it can be concluded that green tea (polyphenol catechins and EGCG) causes proliferation of fibroblasts and affects the functional capacity of fibroblasts and increases the ability to synthesize collagen fibers.